New cause of penicillin treatment failure.

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Treatment failure with penicillin in early syphilis.

A patient with primary syphilis had a recurrence of his penile chancre after generally acceptable penicillin treatment. Retreatment with a similar but extended penicillin regimen was successful. This is the first report of such a treatment failure.

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Congestive failure has been considered a relative contraindication to antisyphilitic therapy in cardiovascular syphilis since the arsphenamine era, when severe reactions were reported following administration of this vasculotoxic drug. After having observed no severe reactions to penicillin in a series of patients with cardiovascular syphilis, it was decided to administer the antibiotic as init...

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Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia.

OBJECTIVE To determine whether the presence of in vitro penicillin-resistant Streptococcus pneumoniae increases the risk of clinical failure in children hospitalised with severe pneumonia and treated with penicillin/ampicillin. DESIGN Multicentre, prospective, observational study. SETTING 12 tertiary-care centres in three countries in Latin America. PATIENTS 240 children aged 3-59 months,...

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ژورنال

عنوان ژورنال: BMJ

سال: 1977

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.1.6067.991